A study on a rare case of sebaceous adenoma on the eyelid was published on April 2, 2026, in Volume 13 of the journal Oncoscience. Gunvanti Rathod, from the Department of Pathology and Laboratory Medicine at the All India Institute of Medical Sciences, served as the first and corresponding author of the study.
Sebaceous adenoma is a benign tumor originating from sebaceous glands, and its occurrence on the eyelid is uncommon. The study detailed an 81-year-old male patient who presented with a slowly enlarging lesion on his lower left eyelid. This lesion gradually increased in size over several years and exhibited a yellowish-pink papillomatous appearance.
Clinical presentation of sebaceous adenomas can be similar to other benign growths or malignant tumors. Histopathological examination is typically required to distinguish sebaceous adenoma from sebaceous carcinoma. Microscopic examination of the patient's lesion revealed well-circumscribed lobules composed of mature sebocytes with vacuolated cytoplasm, surrounded by a peripheral layer of basaloid cells. The lesion did not show nuclear atypia, necrosis, or notable mitotic activity.
Further testing included immunohistochemical analysis, which showed positive staining for epithelial membrane antigen. Ki-67 testing indicated a proliferative index of less than 5 percent for the lesion. The patient's medical history did not suggest Muir-Torre syndrome, a hereditary cancer predisposition syndrome linked to defects in DNA mismatch repair genes. Gunvanti Rathod stated, "Sebaceous adenoma of the eyelid is a rare, benign sebaceous neoplasm that can mimic papillomatous or malignant lesions."
No independent assessment of Gunvanti Rathod’s claims was available.